![]() Visser PJ, Verhey F, Knol DL, Scheltens P, Wahlund LO, Freund-Levi Y, Tsolaki M, Minthon L, Wallin AK, Hampel H, Bürger K, Pirttila T, Soininen H, Rikkert MO, Verbeek MM, Spiru L, Blennow K (2009) Prevalence and prognostic value of CSF markers of Alzheimer’s disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study. īutler CR, Bhaduri A, Acosta-Cabronero J, Nestor PJ, Kapur N, Graham KS, Hodges JR, Zeman AZ (2009) Transient epileptic amnesia: regional brain atrophy and its relationship to memory deficits. Ĭretin B, Blanc F, Gaultier C, Sellal F (2012) Epileptic amnesic syndrome revealing Alzheimer’s disease. Ĭretin B, Philippi N, Sellal F, Dibitonto L, Martin-Hunyadi C, Blanc F (2014) Can the syndrome of transient epileptic amnesia be the first feature of Alzheimer’s disease? Seizure 23(10):918–920. īaker J, Savage S, Milton F, Butler C, Kapur N, Hodges J, Zeman A (2021) The syndrome of transient epileptic amnesia: a combined series of 115 cases and literature review. Ramanan VK, Morris KA, Graff-Radford J, Jones DT, Burkholder DB, Britton JW, Josephs KA, Boeve BF, Savica R (2019) Transient epileptic amnesia: a treatable cause of spells associated with persistent cognitive symptoms. (17)30044-3.PMID:28327340 PMCID:PMC5973551Ĭretin B, Sellal F, Philippi N, Bousiges O, Di Bitonto L, Martin-Hunyadi C, Blanc F (2016) Epileptic prodromal Alzheimer’s disease, a retrospective study of 13 new cases: expanding the spectrum of Alzheimer’s disease to an epileptic variant? J Alzheimers Dis 52(3):1125–1133. Vossel KA, Tartaglia MC, Nygaard HB, Zeman AZ, Miller BL (2017) Epileptic activity in Alzheimer’s disease: causes and clinical relevance. Savage SA, Baker J, Milton F, Butler C, Zeman A (2022) Clinical outcomes in transient epileptic amnesia: a 10-year follow-up cohort study of 47 cases. Savage SA, Butler CR, Hodges JR, Zeman AZ (2016) Transient epileptic amnesia over twenty years: long-term follow-up of a case series with three detailed reports. ![]() īlain A, Sellal F, Philippi N, Blanc F, Cretin B (2021) Transient epileptic amnesia is significantly associated with discrete CA1-located hippocampal calcifications but not with atrophic changes on brain imaging. Mosbah A, Tramoni E, Guedj E, Aubert S, Daquin G, Ceccaldi M, Félician O, Bartolomei F (2014) Clinical, neuropsychological, and metabolic characteristics of transient epileptic amnesia syndrome. PMCID:PMC2170058īutler CR, Graham KS, Hodges JR, Kapur N, Wardlaw JM, Zeman AZ (2007) The syndrome of transient epileptic amnesia. J Neurol Neurosurg Psychiatry 64(4):435–443. Zeman AZ, Boniface SJ, Hodges JR (1998) Transient epileptic amnesia: a description of the clinical and neuropsychological features in 10 cases and a review of the literature. More broadly, our results suggest an etiological heterogeneity in TEA. It argues for TEA being the inaugurating feature in some cases of AD. This study shows a good diagnostic value of CSF sampling in a specific population of TEA with characteristics suggestive of incipient degenerative diseases (i.e., red flags). CSF analyses revealed amyloid and/or tau changes in 27 patients (38%), including an Alzheimer’s disease (AD) profile in 17 (24%). At follow-up, the CSF-TEA group had significantly ( p < 0.01) lower MMSE scores (27.8 vs. 42.6%), and more atrophic hippocampal changes. ![]() 28.9), a more frequent amnestic mild cognitive impairment profile (69% vs. 9.4%), a lower baseline MMSE score (27 vs. 10.7%), a more blunted sense of smell (34.3% vs. ResultsĪt baseline, the CSF-TEA group had significantly ( p < 0.01) more frequent mild parkinsonism (42.9% vs. CSF samples were examined for amyloid β-42 peptide as well as phospho-tau and total-tau levels. Both were compared for demographics medical history baseline neurological, cognitive, and behavioral features baseline mesial temporal lobe atrophy and cognitive follow-up at a median of 13 months. In this retrospective study, 127 TEA patients with unremarkable imaging findings were divided into 2 groups, namely, CSF ( n = 71) and no-CSF ( n = 56). We, therefore, examined the yield of CSF amyloid and tau biomarkers in TEA. Transient epileptic amnesia (TEA) is a late-onset epilepsy syndrome encompassing transient iterative amnesias and interictal cognitive impairment, two features that overlap with incipient neurodegenerative dementias.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |